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Concurrently, high glucose suppressed the tumor suppressor TIF1, further amplifying Smad-mediated transcription and elevating the expression of pro-oncogenic genes, including the epithelialmesenchymal transition markers N-cadherin and vimentin, thereby collectively fostering CRC progression
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Critically, 35 of these 36 studies were preclinical animal experiments
Biochem J 1991
Haritos VS et al
La tirzepatida (Mounjaro, Zepbound) es un agonista dual que acta sobre los receptores GIP y GLP-1, no un agonista GLP-1 puro
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